International Journal of Healthcare and Medical Sciences
Online ISSN: 2414-2999
Print ISSN: 2415-5233
Print ISSN: 2415-5233
Quarterly Published (4 Issues Per Year)
Archives
Volume 5 Number 10 October 2019
Matrixmetalloproteinase-9 Genetic Variation with Cataract, Glaucoma and Retinoblastoma in a Senegalese Population
Authors: Matar Ciss ; Ndéye Ndoumbé Guéye ; Fatimata Mbaye ; Paul Aїda Ndoye ; Chérif Dial ; Joseph Ndiaye ; Mbacké Sembéne
Pages: 52-58
DOI: doi.org/10.32861/ijhms.510.52.58
Abstract
The Matrix metalloproteinase-9 is involved in several pathologies. Its strong presence in ocular pathologies explains our interest for its genetic variation in cataract, glaucoma and retinoblastoma in Senegal. MMP9 is highly polymorphic with cataract and glaucoma. 77 mutations were noted with 21 haplotypes for the entire population. The haplotype diversity Hd is 0.831 and the nucleotide diversity Pi is 0.016; k = 17.395. The polymorphism of the Matrix metalloproteinase-9 gene is associated with all three diseases and SNP 3918249 is found in both cataract and glaucoma.
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